A: No. The whole point of the registry file is to avoid reinstallation. As long as your game folder is intact, only the registry entries are missing.
Windows Registry Editor Version 5.00 [HKEY_LOCAL_MACHINE\SOFTWARE\Wow6432Node\KONAMI\PES2010] "code"="YOUR-SERIAL-KEY-HERE" "installdir"="C:\\Program Files (x86)\\KONAMI\\Pro Evolution Soccer 2010\\" "version"="1.00.0000" Use code with caution. Copied to clipboard Pes 2010 Registry File For Windows 7 64 Bit -NEW
To fix the installation path, follow these steps to "put together" the piece: on your computer. Copy and paste the following code exactly as shown: Pes 2010 Registry File For Windows 7 64 Bit -NEW