This often means the fix version doesn't match your game's current update version. Check the mod page for an updated "v1.1" or "v1.2" patch that matches the latest Steam or Epic Games Store build.
If you are running an older enthusiast processor or certain budget Intel Pentium/Celeron chips, the lack of AVX2 is the exact reason your game refuses to launch. Community Fixes and Bypass Methods uncharted 4 avx2 fix
Enable/disable CPU features in BIOS (if applicable) This often means the fix version doesn't match
Uncharted 4 relies heavily on these instructions to handle its massive environments and complex physics. If the game tries to execute an AVX2 instruction on an older CPU that does not understand it, the processor throws an error, and the game instantly crashes. This primarily impacts players running older, yet still competent, hardware such as: the processor throws an error
If you're still having trouble launching the game, follow this diagnostic flow: