End of report.
If those fail, proceed to the surgical fixes below. End of report
Delete every file and folder for the following two items: End of report. If those fail
Open ( Ctrl + Shift + Esc ) and ensure no "Steam" or "RE4" processes are still running. the Steam client
Ensure Steam Overlay and Steam Client are allowed
The message "Steam must be running to play this game" for Resident Evil 4 is almost never a real Steam absence—it is a between the game, the Steam client, and your operating system.