The season opens with the CBI team dealing with a series of crimes linked to the Red Joker. As the season progresses, viewers are introduced to more complex cases, character backstories, and interpersonal relationships within the team. The dynamic between Patrick Jane and his colleagues, including Teresa Lisbon (Robin Tunney), Kimball Cho (Owain Yeoman), and Wayne Rigsby (Pruitt Taylor Vince), adds depth to the show, balancing humor with the darker themes of crime and justice.

Final musim kedua, yang berjudul "Red Sky at Night" , sering dianggap sebagai salah satu episode terbaik dalam sejarah serial ini, di mana Jane akhirnya bertatap muka (meski secara tidak langsung) dengan Red John.

Beberapa platform legal menyediakan The Mentalist dengan pilihan subtitle Bahasa Indonesia: