The most reliable method is to isolate the software inside an environment it natively understands.
between host and guest, or mount the Syswin 3.4 ISO.
Syswin (System Windows) was Omron’s flagship DOS/Windows-based PLC programming software from the mid-1990s to the early 2000s. It succeeded the DOS-only SSS (SYSMAC Support Software) and preceded CX-One (which includes CX-Programmer).
Once the gold standard for programming Omron’s classic C-series PLCs (like the CPM1, CQM1, and C200H), was built for an era of 486 and Pentium processors. Because it is a 16-bit application , it cannot run natively on any 64-bit version of Windows. For engineers today, trying to open it on Windows 10 or 11 usually results in a cold, "This app can't run on your PC" error. The Modern Quest